Inability of rat DPP4 to allow MERS-CoV infection revealed by using a VSV pseudotype bearing truncated MERS-CoV spike protein
Identifieur interne : 001749 ( Main/Exploration ); précédent : 001748; suivant : 001750Inability of rat DPP4 to allow MERS-CoV infection revealed by using a VSV pseudotype bearing truncated MERS-CoV spike protein
Auteurs : Aiko Fukuma ; Hideki Tani ; Satoshi Taniguchi ; Masayuki Shimojima ; Masayuki Saijo ; Shuetsu FukushiSource :
- Archives of Virology [ 0304-8608 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Attachement viral, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Dipeptidyl peptidase 4 (métabolisme), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (métabolisme), Rats, Récepteurs viraux (métabolisme), Vecteurs génétiques, Vesiculovirus (génétique).
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Vesiculovirus.
- métabolisme : Dipeptidyl peptidase 4, Glycoprotéine de spicule des coronavirus, Récepteurs viraux.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- Animaux, Attachement viral, Rats, Vecteurs génétiques.
English descriptors
- KwdEn :
- Animals, Dipeptidyl Peptidase 4 (metabolism), Genetic Vectors, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (physiology), Rats, Receptors, Virus (metabolism), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (metabolism), Vesiculovirus (genetics), Virus Attachment.
- MESH :
- chemical , genetics : Spike Glycoprotein, Coronavirus.
- chemical , metabolism : Dipeptidyl Peptidase 4, Receptors, Virus, Spike Glycoprotein, Coronavirus.
- genetics : Middle East Respiratory Syndrome Coronavirus, Vesiculovirus.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- Animals, Genetic Vectors, Rats, Virus Attachment.
Abstract
Middle East respiratory syndrome (MERS) coronavirus (Co-V) contains a single spike (S) protein, which binds to a receptor molecule, dipeptidyl peptidase 4 (DPP4; also known as CD26), and serves as a neutralizing antigen. Pseudotyped viruses are useful for measuring neutralization titers against highly infectious viruses as well as for studying their mechanism of entry. In this study, we constructed a series of cytoplasmic deletion mutants of MERS-CoV S and compared the efficiency with which they formed pseudotypes with vesicular stomatitis virus. A pseudotype bearing an S protein with the C-terminal 16 amino acids deleted (MERSpv-St16) reached a maximum titer that was approximately tenfold higher than that of a pseudotype bearing a non-truncated full-length S protein. Using MERSpv-St16, we demonstrated the inability of rat DPP4 to serve as a functional receptor for MERS-CoV, suggesting that rats are not susceptible to MERS-CoV infection. This study provides novel information that enhances our understanding of the host range of MERS-CoV.
The online version of this article (doi:10.1007/s00705-015-2506-z) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s00705-015-2506-z
PubMed: 26138557
PubMed Central: 7086748
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000252
- to stream Pmc, to step Curation: 000252
- to stream Pmc, to step Checkpoint: 000E29
- to stream PubMed, to step Corpus: 001562
- to stream PubMed, to step Curation: 001562
- to stream PubMed, to step Checkpoint: 001512
- to stream Ncbi, to step Merge: 001177
- to stream Ncbi, to step Curation: 001177
- to stream Ncbi, to step Checkpoint: 001177
- to stream Main, to step Merge: 001754
- to stream Main, to step Curation: 001749
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inability of rat DPP4 to allow MERS-CoV infection revealed by using a VSV pseudotype bearing truncated MERS-CoV spike protein</title><author><name sortKey="Fukuma, Aiko" sort="Fukuma, Aiko" uniqKey="Fukuma A" first="Aiko" last="Fukuma">Aiko Fukuma</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Tani, Hideki" sort="Tani, Hideki" uniqKey="Tani H" first="Hideki" last="Tani">Hideki Tani</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Taniguchi, Satoshi" sort="Taniguchi, Satoshi" uniqKey="Taniguchi S" first="Satoshi" last="Taniguchi">Satoshi Taniguchi</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Shimojima, Masayuki" sort="Shimojima, Masayuki" uniqKey="Shimojima M" first="Masayuki" last="Shimojima">Masayuki Shimojima</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Saijo, Masayuki" sort="Saijo, Masayuki" uniqKey="Saijo M" first="Masayuki" last="Saijo">Masayuki Saijo</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Fukushi, Shuetsu" sort="Fukushi, Shuetsu" uniqKey="Fukushi S" first="Shuetsu" last="Fukushi">Shuetsu Fukushi</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26138557</idno><idno type="pmc">7086748</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086748</idno><idno type="RBID">PMC:7086748</idno><idno type="doi">10.1007/s00705-015-2506-z</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000252</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000252</idno><idno type="wicri:Area/Pmc/Curation">000252</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000252</idno><idno type="wicri:Area/Pmc/Checkpoint">000E29</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E29</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:26138557</idno><idno type="wicri:Area/PubMed/Corpus">001562</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001562</idno><idno type="wicri:Area/PubMed/Curation">001562</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001562</idno><idno type="wicri:Area/PubMed/Checkpoint">001512</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001512</idno><idno type="wicri:Area/Ncbi/Merge">001177</idno><idno type="wicri:Area/Ncbi/Curation">001177</idno><idno type="wicri:Area/Ncbi/Checkpoint">001177</idno><idno type="wicri:doubleKey">0304-8608:2015:Fukuma A:inability:of:rat</idno><idno type="wicri:Area/Main/Merge">001754</idno><idno type="wicri:Area/Main/Curation">001749</idno><idno type="wicri:Area/Main/Exploration">001749</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Inability of rat DPP4 to allow MERS-CoV infection revealed by using a VSV pseudotype bearing truncated MERS-CoV spike protein</title><author><name sortKey="Fukuma, Aiko" sort="Fukuma, Aiko" uniqKey="Fukuma A" first="Aiko" last="Fukuma">Aiko Fukuma</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Tani, Hideki" sort="Tani, Hideki" uniqKey="Tani H" first="Hideki" last="Tani">Hideki Tani</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Taniguchi, Satoshi" sort="Taniguchi, Satoshi" uniqKey="Taniguchi S" first="Satoshi" last="Taniguchi">Satoshi Taniguchi</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Shimojima, Masayuki" sort="Shimojima, Masayuki" uniqKey="Shimojima M" first="Masayuki" last="Shimojima">Masayuki Shimojima</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Saijo, Masayuki" sort="Saijo, Masayuki" uniqKey="Saijo M" first="Masayuki" last="Saijo">Masayuki Saijo</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Fukushi, Shuetsu" sort="Fukushi, Shuetsu" uniqKey="Fukushi S" first="Shuetsu" last="Fukushi">Shuetsu Fukushi</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Archives of Virology</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Dipeptidyl Peptidase 4 (metabolism)</term><term>Genetic Vectors</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Rats</term><term>Receptors, Virus (metabolism)</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (metabolism)</term><term>Vesiculovirus (genetics)</term><term>Virus Attachment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Attachement viral</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Dipeptidyl peptidase 4 (métabolisme)</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (métabolisme)</term><term>Rats</term><term>Récepteurs viraux (métabolisme)</term><term>Vecteurs génétiques</term><term>Vesiculovirus (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>Receptors, Virus</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>Vesiculovirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Vesiculovirus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dipeptidyl peptidase 4</term><term>Glycoprotéine de spicule des coronavirus</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genetic Vectors</term><term>Rats</term><term>Virus Attachment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Attachement viral</term><term>Rats</term><term>Vecteurs génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Middle East respiratory syndrome (MERS) coronavirus (Co-V) contains a single spike (S) protein, which binds to a receptor molecule, dipeptidyl peptidase 4 (DPP4; also known as CD26), and serves as a neutralizing antigen. Pseudotyped viruses are useful for measuring neutralization titers against highly infectious viruses as well as for studying their mechanism of entry. In this study, we constructed a series of cytoplasmic deletion mutants of MERS-CoV S and compared the efficiency with which they formed pseudotypes with vesicular stomatitis virus. A pseudotype bearing an S protein with the C-terminal 16 amino acids deleted (MERSpv-St16) reached a maximum titer that was approximately tenfold higher than that of a pseudotype bearing a non-truncated full-length S protein. Using MERSpv-St16, we demonstrated the inability of rat DPP4 to serve as a functional receptor for MERS-CoV, suggesting that rats are not susceptible to MERS-CoV infection. This study provides novel information that enhances our understanding of the host range of MERS-CoV.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1007/s00705-015-2506-z) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abroug, F" uniqKey="Abroug F">F Abroug</name></author><author><name sortKey="Slim, A" uniqKey="Slim A">A Slim</name></author><author><name sortKey="Ouanes Besbes, L" uniqKey="Ouanes Besbes L">L Ouanes-Besbes</name></author><author><name sortKey="Hadj Kacem, Ma" uniqKey="Hadj Kacem M">MA Hadj Kacem</name></author><author><name sortKey="Dachraoui, F" uniqKey="Dachraoui F">F Dachraoui</name></author><author><name sortKey="Ouanes, I" uniqKey="Ouanes I">I Ouanes</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Tao, Y" uniqKey="Tao Y">Y Tao</name></author><author><name sortKey="Paden, C" uniqKey="Paden C">C Paden</name></author><author><name sortKey="Caidi, H" uniqKey="Caidi H">H Caidi</name></author><author><name sortKey="Miao, C" uniqKey="Miao C">C Miao</name></author><author><name sortKey="Al Hajri, Mm" uniqKey="Al Hajri M">MM Al-Hajri</name></author><author><name sortKey="Zorraga, M" uniqKey="Zorraga M">M Zorraga</name></author><author><name sortKey="Ghaouar, W" uniqKey="Ghaouar W">W Ghaouar</name></author><author><name sortKey="Bensalah, A" uniqKey="Bensalah A">A BenSalah</name></author><author><name sortKey="Gerber, Si" uniqKey="Gerber S">SI Gerber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barlan, A" uniqKey="Barlan A">A Barlan</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Sarkar, Mk" uniqKey="Sarkar M">MK Sarkar</name></author><author><name sortKey="Li, K" uniqKey="Li K">K Li</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bukbuk, Dn" uniqKey="Bukbuk D">DN Bukbuk</name></author><author><name sortKey="Fukushi, S" uniqKey="Fukushi S">S Fukushi</name></author><author><name sortKey="Tani, H" uniqKey="Tani H">H Tani</name></author><author><name sortKey="Yoshikawa, T" uniqKey="Yoshikawa T">T Yoshikawa</name></author><author><name sortKey="Taniguchi, S" uniqKey="Taniguchi S">S Taniguchi</name></author><author><name sortKey="Iha, K" uniqKey="Iha K">K Iha</name></author><author><name sortKey="Fukuma, A" uniqKey="Fukuma A">A Fukuma</name></author><author><name sortKey="Shimojima, M" uniqKey="Shimojima M">M Shimojima</name></author><author><name sortKey="Morikawa, S" uniqKey="Morikawa S">S Morikawa</name></author><author><name sortKey="Saijo, M" uniqKey="Saijo M">M Saijo</name></author><author><name sortKey="Kasolo, F" uniqKey="Kasolo F">F Kasolo</name></author><author><name sortKey="Baba, Ss" uniqKey="Baba S">SS Baba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Choi, Gk" uniqKey="Choi G">GK Choi</name></author><author><name sortKey="To, Kk" uniqKey="To K">KK To</name></author><author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name></author><author><name sortKey="Cai, Jp" uniqKey="Cai J">JP Cai</name></author><author><name sortKey="Yeung, Ml" uniqKey="Yeung M">ML Yeung</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Che, Xy" uniqKey="Che X">XY Che</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name></author><author><name sortKey="Peck, Km" uniqKey="Peck K">KM Peck</name></author><author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name></author><author><name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name></author><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name></author><author><name sortKey="Curnes, Nr" uniqKey="Curnes N">NR Curnes</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Heise, Mt" uniqKey="Heise M">MT Heise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name></author><author><name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name></author><author><name sortKey="Okumura, A" uniqKey="Okumura A">A Okumura</name></author><author><name sortKey="Peng, X" uniqKey="Peng X">X Peng</name></author><author><name sortKey="Thomas, Mj" uniqKey="Thomas M">MJ Thomas</name></author><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Haddock, E" uniqKey="Haddock E">E Haddock</name></author><author><name sortKey="Nagy, L" uniqKey="Nagy L">L Nagy</name></author><author><name sortKey="Lacasse, R" uniqKey="Lacasse R">R LaCasse</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name></author><author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name></author><author><name sortKey="Mclellan, Js" uniqKey="Mclellan J">JS McLellan</name></author><author><name sortKey="Scott, Dp" uniqKey="Scott D">DP Scott</name></author><author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fanoy, Eb" uniqKey="Fanoy E">EB Fanoy</name></author><author><name sortKey="Van Der Sande, Ma" uniqKey="Van Der Sande M">MA van der Sande</name></author><author><name sortKey="Kraaij Dirkzwager, M" uniqKey="Kraaij Dirkzwager M">M Kraaij-Dirkzwager</name></author><author><name sortKey="Dirksen, K" uniqKey="Dirksen K">K Dirksen</name></author><author><name sortKey="Jonges, M" uniqKey="Jonges M">M Jonges</name></author><author><name sortKey="Van Der Hoek, W" uniqKey="Van Der Hoek W">W van der Hoek</name></author><author><name sortKey="Koopmans, Mp" uniqKey="Koopmans M">MP Koopmans</name></author><author><name sortKey="Van Der Werf, D" uniqKey="Van Der Werf D">D van der Werf</name></author><author><name sortKey="Sonder, G" uniqKey="Sonder G">G Sonder</name></author><author><name sortKey="Van Der Weijden, C" uniqKey="Van Der Weijden C">C van der Weijden</name></author><author><name sortKey="Van Der Heuvel, J" uniqKey="Van Der Heuvel J">J van der Heuvel</name></author><author><name sortKey="Gelinck, L" uniqKey="Gelinck L">L Gelinck</name></author><author><name sortKey="Bouwhuis, Jw" uniqKey="Bouwhuis J">JW Bouwhuis</name></author><author><name sortKey="Van Gageldonk Lafeber, Ab" uniqKey="Van Gageldonk Lafeber A">AB van Gageldonk-Lafeber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fukushi, S" uniqKey="Fukushi S">S Fukushi</name></author><author><name sortKey="Mizutani, T" uniqKey="Mizutani T">T Mizutani</name></author><author><name sortKey="Saijo, M" uniqKey="Saijo M">M Saijo</name></author><author><name sortKey="Matsuyama, S" uniqKey="Matsuyama S">S Matsuyama</name></author><author><name sortKey="Miyajima, N" uniqKey="Miyajima N">N Miyajima</name></author><author><name sortKey="Taguchi, F" uniqKey="Taguchi F">F Taguchi</name></author><author><name sortKey="Itamura, S" uniqKey="Itamura S">S Itamura</name></author><author><name sortKey="Kurane, I" uniqKey="Kurane I">I Kurane</name></author><author><name sortKey="Morikawa, S" uniqKey="Morikawa S">S Morikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fukushi, S" uniqKey="Fukushi S">S Fukushi</name></author><author><name sortKey="Nakauchi, M" uniqKey="Nakauchi M">M Nakauchi</name></author><author><name sortKey="Mizutani, T" uniqKey="Mizutani T">T Mizutani</name></author><author><name sortKey="Saijo, M" uniqKey="Saijo M">M Saijo</name></author><author><name sortKey="Kurane, I" uniqKey="Kurane I">I Kurane</name></author><author><name sortKey="Morikawa, S" uniqKey="Morikawa S">S Morikawa</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F Gao</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Bao, J" uniqKey="Bao J">J Bao</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Mj" uniqKey="Moore M">MJ Moore</name></author><author><name sortKey="Dorfman, T" uniqKey="Dorfman T">T Dorfman</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Wong, Sk" uniqKey="Wong S">SK Wong</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Kuhn, Jh" uniqKey="Kuhn J">JH Kuhn</name></author><author><name sortKey="Coderre, J" uniqKey="Coderre J">J Coderre</name></author><author><name sortKey="Vasilieva, N" uniqKey="Vasilieva N">N Vasilieva</name></author><author><name sortKey="Han, Z" uniqKey="Han Z">Z Han</name></author><author><name sortKey="Greenough, Tc" uniqKey="Greenough T">TC Greenough</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author><author><name sortKey="Choe, H" uniqKey="Choe H">H Choe</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nowotny, N" uniqKey="Nowotny N">N Nowotny</name></author><author><name sortKey="Kolodziejek, J" uniqKey="Kolodziejek J">J Kolodziejek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogino, M" uniqKey="Ogino M">M Ogino</name></author><author><name sortKey="Ebihara, H" uniqKey="Ebihara H">H Ebihara</name></author><author><name sortKey="Lee, Bh" uniqKey="Lee B">BH Lee</name></author><author><name sortKey="Araki, K" uniqKey="Araki K">K Araki</name></author><author><name sortKey="Lundkvist, A" uniqKey="Lundkvist A">A Lundkvist</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author><author><name sortKey="Yoshimatsu, K" uniqKey="Yoshimatsu K">K Yoshimatsu</name></author><author><name sortKey="Arikawa, J" uniqKey="Arikawa J">J Arikawa</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Dekkers, Dh" uniqKey="Dekkers D">DH Dekkers</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Demmers, Ja" uniqKey="Demmers J">JA Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A Zaki</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Provacia, Lb" uniqKey="Provacia L">LB Provacia</name></author><author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name></author><author><name sortKey="Wiersma, L" uniqKey="Wiersma L">L Wiersma</name></author><author><name sortKey="Ouwendijk, Wj" uniqKey="Ouwendijk W">WJ Ouwendijk</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Spronken, Mi" uniqKey="Spronken M">MI Spronken</name></author><author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G van Amerongen</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Gutierrez, C" uniqKey="Gutierrez C">C Gutierrez</name></author><author><name sortKey="Godeke, Gj" uniqKey="Godeke G">GJ Godeke</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Smits De Vries, L" uniqKey="Smits De Vries L">L Smits-De Vries</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Drexler, Jf" uniqKey="Drexler J">JF Drexler</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="El Tahir, Ye" uniqKey="El Tahir Y">YE El Tahir</name></author><author><name sortKey="De Sousa, R" uniqKey="De Sousa R">R De Sousa</name></author><author><name sortKey="Van Beek, J" uniqKey="Van Beek J">J van Beek</name></author><author><name sortKey="Nowotny, N" uniqKey="Nowotny N">N Nowotny</name></author><author><name sortKey="Van Maanen, K" uniqKey="Van Maanen K">K van Maanen</name></author><author><name sortKey="Hidalgo Hermoso, E" uniqKey="Hidalgo Hermoso E">E Hidalgo-Hermoso</name></author><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author><author><name sortKey="Rottier, P" uniqKey="Rottier P">P Rottier</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author><author><name sortKey="Gortazar Schmidt, C" uniqKey="Gortazar Schmidt C">C Gortazar-Schmidt</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Koopmans, Mp" uniqKey="Koopmans M">MP Koopmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsiodras, S" uniqKey="Tsiodras S">S Tsiodras</name></author><author><name sortKey="Baka, A" uniqKey="Baka A">A Baka</name></author><author><name sortKey="Mentis, A" uniqKey="Mentis A">A Mentis</name></author><author><name sortKey="Iliopoulos, D" uniqKey="Iliopoulos D">D Iliopoulos</name></author><author><name sortKey="Dedoukou, X" uniqKey="Dedoukou X">X Dedoukou</name></author><author><name sortKey="Papamavrou, G" uniqKey="Papamavrou G">G Papamavrou</name></author><author><name sortKey="Karadima, S" uniqKey="Karadima S">S Karadima</name></author><author><name sortKey="Emmanouil, M" uniqKey="Emmanouil M">M Emmanouil</name></author><author><name sortKey="Kossyvakis, A" uniqKey="Kossyvakis A">A Kossyvakis</name></author><author><name sortKey="Spanakis, N" uniqKey="Spanakis N">N Spanakis</name></author><author><name sortKey="Pavli, A" uniqKey="Pavli A">A Pavli</name></author><author><name sortKey="Maltezou, H" uniqKey="Maltezou H">H Maltezou</name></author><author><name sortKey="Karageorgou, A" uniqKey="Karageorgou A">A Karageorgou</name></author><author><name sortKey="Spala, G" uniqKey="Spala G">G Spala</name></author><author><name sortKey="Pitiriga, V" uniqKey="Pitiriga V">V Pitiriga</name></author><author><name sortKey="Kosmas, E" uniqKey="Kosmas E">E Kosmas</name></author><author><name sortKey="Tsiagklis, S" uniqKey="Tsiagklis S">S Tsiagklis</name></author><author><name sortKey="Gkatzias, S" uniqKey="Gkatzias S">S Gkatzias</name></author><author><name sortKey="Koulouris, N" uniqKey="Koulouris N">N Koulouris</name></author><author><name sortKey="Koutsoukou, A" uniqKey="Koutsoukou A">A Koutsoukou</name></author><author><name sortKey="Bakakos, P" uniqKey="Bakakos P">P Bakakos</name></author><author><name sortKey="Markozanhs, E" uniqKey="Markozanhs E">E Markozanhs</name></author><author><name sortKey="Dionellis, G" uniqKey="Dionellis G">G Dionellis</name></author><author><name sortKey="Pontikis, K" uniqKey="Pontikis K">K Pontikis</name></author><author><name sortKey="Rovina, N" uniqKey="Rovina N">N Rovina</name></author><author><name sortKey="Kyriakopoulou, M" uniqKey="Kyriakopoulou M">M Kyriakopoulou</name></author><author><name sortKey="Efstathiou, P" uniqKey="Efstathiou P">P Efstathiou</name></author><author><name sortKey="Papadimitriou, T" uniqKey="Papadimitriou T">T Papadimitriou</name></author><author><name sortKey="Kremastinou, J" uniqKey="Kremastinou J">J Kremastinou</name></author><author><name sortKey="Tsakris, A" uniqKey="Tsakris A">A Tsakris</name></author><author><name sortKey="Saroglou, G" uniqKey="Saroglou G">G Saroglou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Miazgowicz, Kl" uniqKey="Miazgowicz K">KL Miazgowicz</name></author><author><name sortKey="Milne Price, S" uniqKey="Milne Price S">S Milne-Price</name></author><author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T Bushmaker</name></author><author><name sortKey="Robertson, S" uniqKey="Robertson S">S Robertson</name></author><author><name sortKey="Scott, D" uniqKey="Scott D">D Scott</name></author><author><name sortKey="Kinne, J" uniqKey="Kinne J">J Kinne</name></author><author><name sortKey="Mclellan, Js" uniqKey="Mclellan J">JS McLellan</name></author><author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Tong, P" uniqKey="Tong P">P Tong</name></author><author><name sortKey="Guo, D" uniqKey="Guo D">D Guo</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L Fu</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y Cui</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Arledge, Kc" uniqKey="Arledge K">KC Arledge</name></author><author><name sortKey="Chen, Yh" uniqKey="Chen Y">YH Chen</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Poon, Vk" uniqKey="Poon V">VK Poon</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Li, K" uniqKey="Li K">K Li</name></author><author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name></author><author><name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name></author><author><name sortKey="Fett, C" uniqKey="Fett C">C Fett</name></author><author><name sortKey="Gale, Mj" uniqKey="Gale M">MJ Gale</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Fukuma, Aiko" sort="Fukuma, Aiko" uniqKey="Fukuma A" first="Aiko" last="Fukuma">Aiko Fukuma</name><name sortKey="Fukushi, Shuetsu" sort="Fukushi, Shuetsu" uniqKey="Fukushi S" first="Shuetsu" last="Fukushi">Shuetsu Fukushi</name><name sortKey="Saijo, Masayuki" sort="Saijo, Masayuki" uniqKey="Saijo M" first="Masayuki" last="Saijo">Masayuki Saijo</name><name sortKey="Shimojima, Masayuki" sort="Shimojima, Masayuki" uniqKey="Shimojima M" first="Masayuki" last="Shimojima">Masayuki Shimojima</name><name sortKey="Tani, Hideki" sort="Tani, Hideki" uniqKey="Tani H" first="Hideki" last="Tani">Hideki Tani</name><name sortKey="Taniguchi, Satoshi" sort="Taniguchi, Satoshi" uniqKey="Taniguchi S" first="Satoshi" last="Taniguchi">Satoshi Taniguchi</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001749 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001749 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7086748
|texte= Inability of rat DPP4 to allow MERS-CoV infection revealed by using a VSV pseudotype bearing truncated MERS-CoV spike protein
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26138557" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |